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A SINGLE AMINO ACID MUTATION ATTENUATES RUNDOWN OF VOLTAGE-GATED CALCIUM CHANNELS

The activity of voltage-gated calcium channels (VGCCs) decreases with time in whole-cell and inside-out patch-clamp recordings. In this study we found that substituting a single amino acid (I1520) at the intracellular end of IIIS6 in the α(1) subunit of P/Q-type Ca(2+) channels with histidine or asp...

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Bibliografiske detaljer
Main Authors: Zhen, Xiao-guang, Xie, Cheng, Yamada, Yoichi, Zhang, Yun, Doyle, Christina, Yang, Jian
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693970/
https://ncbi.nlm.nih.gov/pubmed/17010345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.09.027
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