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A SINGLE AMINO ACID MUTATION ATTENUATES RUNDOWN OF VOLTAGE-GATED CALCIUM CHANNELS
The activity of voltage-gated calcium channels (VGCCs) decreases with time in whole-cell and inside-out patch-clamp recordings. In this study we found that substituting a single amino acid (I1520) at the intracellular end of IIIS6 in the α(1) subunit of P/Q-type Ca(2+) channels with histidine or asp...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1693970/ https://ncbi.nlm.nih.gov/pubmed/17010345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.09.027 |
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