Why do cytotoxic T lymphocytes fail to eliminate hepatitis C virus? Lessons from studies using major histocompatibility complex class I peptide tetramers.

Hepatitis C virus (HCV) infection is a major public health problem, affecting an estimated 3% of the world's population, and over 10% in some countries. Infection in most cases becomes persistent, and can lead to hepatic inflammation, fibrosis and liver failure. The T lymphocyte reponse, in par...

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Detalhes bibliográficos
Main Authors: Lechner, F, Sullivan, J, Spiegel, H, Nixon, D F, Ferrari, B, Davis, A, Borkowsky, B, Pollack, H, Barnes, E, Dusheiko, G, Klenerman, P
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1692808/
https://ncbi.nlm.nih.gov/pubmed/11186310
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