Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

Huntington's disease (HD) is an autosomal dominant neurodegenerative condition caused by expansions of more than 35 uninterrupted CAG repeats in exon 1 of the huntingtin gene. The CAG repeats in HD and the other seven known diseases caused by CAG codon expansions are translated into long polyglutami...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Carmichael, Jenny, Chatellier, Jean, Woolfson, Adrian, Milstein, César, Fersht, Alan R., Rubinsztein, David C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16928/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10920207/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.170280697
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!