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A covarion-based method for detecting molecular adaptation: application to the evolution of primate mitochondrial genomes.

A new method for detecting site-specific variation of evolutionary rate (the so-called covarion process) from protein sequence data is proposed. It involves comparing the maximum-likelihood estimates of the replacement rate of an amino acid site in distinct subtrees of a large tree. This approach al...

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Detalles Bibliográficos
Autores principales: Pupko, Tal, Galtier, Nicolas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1691038/
https://ncbi.nlm.nih.gov/pubmed/12079652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2002.2025
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