Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity

Targeted disruption of the pp60(src) (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Herein we describe the discovery of a nonpeptide inhibitor (AP22408) of Src that d...

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Main Authors: Shakespeare, William, Yang, Michael, Bohacek, Regine, Cerasoli, Franklin, Stebbins, Karin, Sundaramoorthi, Raji, Azimioara, Mihai, Vu, Chi, Pradeepan, Selvi, Metcalf, Chester, Haraldson, Chad, Merry, Taylor, Dalgarno, David, Narula, Surinder, Hatada, Marcos, Lu, Xiaode, van Schravendijk, Marie Rose, Adams, Susan, Violette, Shelia, Smith, Jeremy, Guan, Wei, Bartlett, Catherine, Herson, Jay, Iuliucci, John, Weigele, Manfred, Sawyer, Tomi
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2000
Assuntos:
Physical Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC16871/
https://ncbi.nlm.nih.gov/pubmed/10944210
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