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Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

We describe a new basis for the construction of a genetic linkage map of the human genome. The basic principle of the mapping scheme is to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms, when hybridized to restriction digests of...

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Autors principals: Botstein, D, White, R L, Skolnick, M, Davis, R W
Format: Artigo
Idioma:Inglês
Publicat: 1980
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1686077/
https://ncbi.nlm.nih.gov/pubmed/6247908
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