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Heterogeneity in late-onset metachromatic leukodystrophy. Effect of inhibitors of cysteine proteinases.

The synthesis of arylsulfatase A polypeptides was followed in fibroblasts from 11 patients with late-onset forms of metachromatic leukodystrophy. In 10 cell lines, the apparent rate of synthesis was 20%-70% as measured by the amount of [35S]arylsulfatase A secreted in the presence of 10 mM NH4Cl. Th...

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Bibliographic Details
Main Authors: von Figura, K, Steckel, F, Conary, J, Hasilik, A, Shaw, E
Format: Artigo
Language:Inglês
Published: 1986
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1683965/
https://ncbi.nlm.nih.gov/pubmed/2876627
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