Identification of a single nucleotide C-to-T transition and five different deletions in patients with severe hemophilia B.

DNA of 70 unrelated hemophilia B patients, including three inhibitor patients, was analyzed by using various restriction enzymes and was hybridized with both a factor IX cDNA and 3'- and 5'-flanking probes. When the gene was mapped this way, six patients all afflicted with severe hemophili...

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Bibliographische Detailangaben
Hauptverfasser: Ludwig, M, Schwaab, R, Eigel, A, Horst, J, Egli, H, Brackmann, H H, Olek, K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1989
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1683389/
https://ncbi.nlm.nih.gov/pubmed/2741941
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