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Functional profile of the human fetal gamma-globin gene upstream promoter region.

We performed a systematic functional analysis of the human gamma-globin promoter to identify its activator domains. We used a panel of truncation and scanning mutants as well as transfection in human K562 fetal erythroid cells. The various mutations produced relatively small changes in promoter func...

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Bibliografische gegevens
Hoofdauteurs: Lin, H J, Han, C Y, Nienhuis, A W
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1992
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1682667/
https://ncbi.nlm.nih.gov/pubmed/1642236
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