The postulated X-inactivation center at Xq27 is most reasonably explained by ascertainment bias: heterozygous expression of recessive mutations is a powerful means of detecting unbalanced X inactivation.

Similar Items

• Familial skewed X inactivation and X-linked mutations: unbalanced X inactivation is a powerful means to ascertain X-linked genes that affect cell proliferation.
  od: Migeon, B R, i dr.
  Izdano: (1998)
• Characterization of a deletion at Xq27-q28 associated with unbalanced inactivation of the nonmutant X chromosome.
  od: Clarke, J T, i dr.
  Izdano: (1992)
• Mapping the gene causing X-linked recessive idiopathic hypoparathyroidism to Xq26-Xq27 by linkage studies.
  od: Thakker, R V, i dr.
  Izdano: (1990)
• Myotubular Myopathy in a Girl with a Deletion at Xq27-q28 and Unbalanced X Inactivation Assigns the MTMI Gene to a 600-kb Region
  od: Dahl, N., i dr.
  Izdano: (1995)
• In search of non-random X inactivation: studies of fetal membranes heterozygous for glucose-6-phosphate dehydrogenase.
  od: Migeon, B R, i dr.
  Izdano: (1979)