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Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy

Selected mutations in the human α4 or β2 neuronal nicotinic acetylcholine receptor subunit genes cosegregate with a partial epilepsy syndrome known as autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To examine possible mechanisms underlying this inherited epilepsy, we engineered two ADN...

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Detalhes bibliográficos
Main Authors: Klaassen, Alwin, Glykys, Joseph, Maguire, Jamie, Labarca, Cesar, Mody, Istvan, Boulter, Jim
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1681351/
https://ncbi.nlm.nih.gov/pubmed/17146052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608215103
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