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Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex
We report that during activation of the simian virus 40 (SV40) pre-replication complex, SV40 T antigen (Tag) helicase actively loads replication protein A (RPA) on emerging single-stranded DNA (ssDNA). This novel loading process requires physical interaction of Tag origin DNA-binding domain (OBD) wi...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2006
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1679769/ https://ncbi.nlm.nih.gov/pubmed/17110927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601432 |
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