Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex

We report that during activation of the simian virus 40 (SV40) pre-replication complex, SV40 T antigen (Tag) helicase actively loads replication protein A (RPA) on emerging single-stranded DNA (ssDNA). This novel loading process requires physical interaction of Tag origin DNA-binding domain (OBD) wi...

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Main Authors: Jiang, Xiaohua, Klimovich, Vitaly, Arunkumar, Alphonse I, Hysinger, Erik B, Wang, Yingda, Ott, Robert D, Guler, Gulfem D, Weiner, Brian, Chazin, Walter J, Fanning, Ellen
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2006
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679769/
https://ncbi.nlm.nih.gov/pubmed/17110927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601432
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