Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate

The lipid second messenger phosphatidylinositol 3-phosphate [PI(3)P] plays a crucial role in intracellular membrane trafficking. We report here that myotubularin, a protein tyrosine phosphatase required for muscle cell differentiation, is a potent PI(3)P phosphatase. Recombinant human myotubularin s...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Taylor, Gregory S., Maehama, Tomohiko, Dixon, Jack E.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2000
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16795/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10900271/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160255697
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