Speeding molecular recognition by using the folding funnel: The fly-casting mechanism
Protein folding and binding are kindred processes. Many proteins in the cell are unfolded, so folding and function are coupled. This paper investigates how binding kinetics is influenced by the folding of a protein. We find that a relatively unstructured protein molecule can have a greater capture r...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16787/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908673/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160259697 |
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