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Adaptation of Puumala Hantavirus to Cell Culture Is Associated with Point Mutations in the Coding Region of the L Segment and in the Noncoding Regions of the S Segment

We previously developed a model for studies on hantavirus host adaptation and initiated genetic analysis of Puumala virus variants passaged in colonized bank voles and in cultured Vero E6 cells. With the data presented in this paper, the sequence comparison of the wild-type and Vero E6-adapted varia...

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Bibliografiske detaljer
Main Authors: Nemirov, Kirill, Lundkvist, Åke, Vaheri, Antti, Plyusnin, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC167242/
https://ncbi.nlm.nih.gov/pubmed/12885898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.16.8793-8800.2003
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