Cell Cycle Arrest by Kaposi's Sarcoma-Associated Herpesvirus Replication-Associated Protein Is Mediated at both the Transcriptional and Posttranslational Levels by Binding to CCAAT/Enhancer-Binding Protein α and p21(CIP-1)

Lytic-cycle replication of Kaposi's sarcoma-associated herpesvirus (KSHV) in PEL cells causes G(1) cell cycle arrest mediated by the virus-encoded replication-associated protein (RAP) (or K8 protein), which induces high-level expression of the cellular C/EBPα and p21 proteins. Here we have exam...

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Main Authors: Wu, Frederick Y., Wang, Shizhen Emily, Tang, Qi-Qun, Fujimuro, Masahiro, Chiou, Chuang-Jiun, Zheng, Qizhi, Chen, Honglin, Hayward, S. Diane, Lane, M. Daniel, Hayward, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC167214/
https://ncbi.nlm.nih.gov/pubmed/12885907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.16.8893-8914.2003
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