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High-Resolution Quantitative Trait Locus Analysis Reveals Multiple Diabetes Susceptibility Loci Mapped to Intervals <800 kb in the Species-Conserved Niddm1i of the GK Rat

Niddm1i, a 16-Mb locus within the major diabetes QTL in the diabetic GK rat, causes impaired glucose tolerance in the congenic NIDDM1I strain. Niddm1i is homologous to both human and mouse regions linked with type 2 diabetes susceptibility. We employed multiple QTL analyses of congenic F(2) progeny...

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Detalhes bibliográficos
Main Authors: Granhall, Charlotte, Park, Hee-Bok, Fakhrai-Rad, Hossein, Luthman, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2006 by the Genetics Society of America 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1667097/
https://ncbi.nlm.nih.gov/pubmed/16951059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.062208
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