Accumulation of quinidine by human blood platelets: Effects on platelet ultrastructure and 5-hydroxytryptamine

1. We have studied the mechanism of quinidine uptake by normal human blood platelets. 2. Platelets in plasma or Krebs solution took up quinidine extremely rapidly, the maximal drug concentration ratio of platelet to medium being 24 to 1 after 1 minute. 3. The effects of metabolic inhibitors on uptak...

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Bibliographic Details
Main Authors: Boullin, D. J., O'Brien, R. A.
Format: Artigo
Language:Inglês
Published: 1971
Subjects:
Pharmacokinetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1666999/
https://ncbi.nlm.nih.gov/pubmed/5580696
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