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New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na(+)-dependent anion leak

The neutral amino acid transporter ASCT2 catalyses uncoupled anion flux across the cell membrane in the presence of transported substrates, such as alanine. Here, we report that ASCT2 conducts anions already in the absence of transported substrates through a leak anion-conducting pathway. The proper...

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Hlavní autoři: Grewer, Christof, Grabsch, Eva
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665628/
https://ncbi.nlm.nih.gov/pubmed/15107471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.062521
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