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New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na(+)-dependent anion leak
The neutral amino acid transporter ASCT2 catalyses uncoupled anion flux across the cell membrane in the presence of transported substrates, such as alanine. Here, we report that ASCT2 conducts anions already in the absence of transported substrates through a leak anion-conducting pathway. The proper...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1665628/ https://ncbi.nlm.nih.gov/pubmed/15107471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.062521 |
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