Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation

A high rate of cardiac work increases citric acid cycle (CAC) turnover and flux through pyruvate dehydrogenase (PDH); however, the mechanisms for these effects are poorly understood. We tested the hypotheses that an increase in cardiac energy expenditure: (1) activates PDH and reduces the product/su...

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Detalhes bibliográficos
Main Authors: Sharma, Naveen, Okere, Isidore C, Brunengraber, Daniel Z, McElfresh, Tracy A, King, Kristen L, Sterk, Joseph P, Huang, Hazel, Chandler, Margaret P, Stanley, William C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Tissue, System and Organ Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665507/
https://ncbi.nlm.nih.gov/pubmed/15550462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.075713
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