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Modulation of excitation–contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca(2+) load and Ca(2+) current trigger
Cardiac Ca(2+) transients are enhanced by cAMP-dependent protein kinase (PKA). However, PKA-dependent modulation of ryanodine receptor (RyR) function in intact cells is difficult to measure, because PKA simultaneously increases Ca(2+) current (I(Ca)), SR Ca(2+) uptake and SR Ca(2+) loading (which in...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1664945/ https://ncbi.nlm.nih.gov/pubmed/14724205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.055384 |
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