Pacing-induced calcineurin activation controls cardiac Ca(2+) signalling and gene expression

Calcineurin, a Ca(2+)–calmodulin-dependent protein phosphatase (PP2B) is one of the links between Ca(2+) signals and regulation of gene transcription in cardiac muscle. We studied the Ca(2+) signal specificity of calcineurin activation experimentally and with modelling. In the rat atrial preparation...

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Autores principales: Tavi, Pasi, Pikkarainen, Sampsa, Ronkainen, Jarkko, Niemelä, Perttu, Ilves, Mika, Weckström, Matti, Vuolteenaho, Olli, Bruton, Joseph, Westerblad, Håkan, Ruskoaho, Heikki
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2004
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1664772/
https://ncbi.nlm.nih.gov/pubmed/14565991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.053579
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