The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

ErbB2 is a receptor tyrosine kinase whose activity in normal cells depends on dimerization with another ligand-binding ErbB receptor. In contrast, amplification of c-erbB2 in tumors results in dramatic overexpression and constitutive activation of the receptor. Breast cancer cells overexpressing Erb...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Holbro, Thomas, Beerli, Roger R., Maurer, Francisca, Koziczak, Magdalena, Barbas, Carlos F., Hynes, Nancy E.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853564/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1537685100
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