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Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2

Cyclooxygenase (COX)-2, a rate-limiting enzyme of prostaglandin (PG) production, is overexpressed in colorectal adenomas and adenocarcinomas, and its inhibition by nonsteroidal antiinflammatory drugs protects against colorectal cancer. Mechanisms of cancer promotion by COX-2 are not fully understood...

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Detalhes bibliográficos
Principais autores: Nishihara, Hiroshi, Kizaka-Kondoh, Shinae, Insel, Paul A., Eckmann, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC166414/
https://ncbi.nlm.nih.gov/pubmed/12837940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1533221100
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