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Electrostatic complementarity in an aldose reductase complex from ultra-high-resolution crystallography and first-principles calculations

The electron density and electrostatic potential in an aldose reductase holoenzyme complex have been studied by density functional theory (DFT) and diffraction methods. Aldose reductase is involved in the reduction of glucose in the polyol pathway by using NADPH as a cofactor. The ultra-high resolut...

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מידע ביבליוגרפי
Main Authors: Muzet, Nicolas, Guillot, Benoît, Jelsch, Christian, Howard, Eduardo, Lecomte, Claude
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2003
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC166383/
https://ncbi.nlm.nih.gov/pubmed/12855766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1432955100
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