Prolonged blood pressure reduction by orally active renin inhibitor RO 42-5892 in essential hypertension.

OBJECTIVE--To investigate the effects of a novel specific renin inhibitor, RO 42-5892, with high affinity for human renin (Ki = 0.5 x 10(-9) mol/l), on plasma renin activity and angiotensin II concentration and on 24 hour ambulatory blood pressure in essential hypertension. DESIGN--Exploratory study...

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Autori principali: van den Meiracker, A H, Admiraal, P J, Man in 't Veld, A J, Derkx, F H, Ritsema van Eck, H J, Mulder, P, van Brummelen, P, Schalekamp, M A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1990
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1663555/
https://ncbi.nlm.nih.gov/pubmed/2203486
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