Replication Checkpoint Kinase Cds1 Regulates Recombinational Repair Protein Rad60

Genome integrity is protected by Cds1 (Chk2), a checkpoint kinase that stabilizes arrested replication forks. How Cds1 accomplishes this task is unknown. We report that Cds1 interacts with Rad60, a protein required for recombinational repair in fission yeast. Cds1 activation triggers Rad60 phosphory...

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Détails bibliographiques
Auteurs principaux: Boddy, Michael N., Shanahan, Paul, Hayes McDonald, W., Lopez-Girona, Antonia, Noguchi, Eishi, Yates III, John R., Russell, Paul
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2003
Sujets:
DNA Dynamics and Chromosome Structure
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC166335/
https://ncbi.nlm.nih.gov/pubmed/12897162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5939-5946.2003
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