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On the kinetics of distamycin binding to its target sites on duplex DNA

Distamycin A is a well known polyamide antibiotic that can bind in the minor groove of duplex DNA primarily at AT-rich sequences both as a monomer or as a side-by-side antiparallel dimer. The association phase of the distamycin binding reaction has not been studied in either of its binding modes, be...

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Autors principals: Baliga, Ramesh, Crothers, Donald M.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC16627/
https://ncbi.nlm.nih.gov/pubmed/10884413
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