ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons

Extracellular signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase family whose biological function in the CNS has not been defined. In contrast to ERK1 and ERK2, which are activated by neurotrophins (NTs), cAMP, and neuronal activity in cortical neurons, ERK5 is acti...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Lidong, Cavanaugh, Jane E., Wang, Yupeng, Sakagami, Hiroyuki, Mao, Zixu, Xia, Zhengui
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2003
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC166263/
https://ncbi.nlm.nih.gov/pubmed/12826611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1332804100
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