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R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms

Langerhans cells (LCs) are suspected to be initial targets for HIV after sexual exposure (by becoming infected or by capturing virus). Here, productive R5 HIV infection of LC ex vivo and LC-mediated transmission of virus to CD4(+) T cells were both found to depend on CCR5. By contrast, infection of...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Kawamura, Tatsuyoshi, Gulden, Forrest O., Sugaya, Makoto, McNamara, David T., Borris, Debra L., Lederman, Michael M., Orenstein, Jan M., Zimmerman, Peter A., Blauvelt, Andrew
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166241/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12815099/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1432450100
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