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Effective Immunomodulatory Treatment of Escherichia coli Experimental Sepsis with Thalidomide

Thalidomide, an agent which inhibits biosynthesis of tumor necrosis factor alpha (TNF-α) and which is used to treat a variety of chronic inflammatory conditions, was investigated as therapy for experimental sepsis. Sepsis was induced by intraperitoneal injection of 10(7) CFU of Escherichia coli per...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Giamarellos-Bourboulis, Evangelos J., Poulaki, Helen, Kostomitsopoulos, Nikolaos, Dontas, Ismene, Perrea, Despina, Karayannacos, Panayotis E., Giamarellou, Helen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166096/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12878503/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.8.2445-2449.2003
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