Characterization of highly frequent epitope-specific CD45RA(+)/CCR7(+/- )T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors

Human polyomavirus BK (BKV) has been implicated in oncogenic transformation. Its ability to replicate is determined by the binding of its large tumor antigen (LTag) to products of tumor-suppressor genes regulating cell cycle, as specifically p53. We investigated CD8+ T immune responses to BKV LTag p...

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Autori principali: Provenzano, Maurizio, Bracci, Laura, Wyler, Stephen, Hudolin, Tvrtko, Sais, Giovanni, Gosert, Rainer, Zajac, Paul, Palu', Giorgio, Heberer, Michael, Hirsch, Hans H, Spagnoli, Giulio C
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2006
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1660549/
https://ncbi.nlm.nih.gov/pubmed/17096832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-4-47
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