Human Alveolar Macrophages Infected by Virulent Bacteria Expressing SipB Are a Major Source of Active Interleukin-18

Recent publications have demonstrated that the protease caspase-1 is responsible for the processing of pro-interleukin 18 (IL-18) into the active form. Studies on cell lines and murine macrophages have shown that the bacterial invasion factor SipB activates caspase-1, triggering cell death. Thus, we...

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Detalhes bibliográficos
Main Authors: Obregon, Carolina, Dreher, Donatus, Kok, Menno, Cochand, Laurence, Kiama, Gitahi S., Nicod, Laurent P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC166028/
https://ncbi.nlm.nih.gov/pubmed/12874316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.8.4382-4388.2003
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