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A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: Application to Mycobacterium tuberculosis

We describe a postgenomic in silico approach for identifying genes that are likely to be essential and estimate their proportion in haploid genomes. With the knowledge of all sites eligible for mutagenesis and an experimentally determined partial list of nonessential genes from genome mutagenesis, a...

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Detalhes bibliográficos
Main Authors: Lamichhane, Gyanu, Zignol, Matteo, Blades, Natalie J., Geiman, Deborah E., Dougherty, Annette, Grosset, Jacques, Broman, Karl W., Bishai, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165855/
https://ncbi.nlm.nih.gov/pubmed/12775759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1231432100
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