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Peripheral heme substituents control the hydrogen-atom abstraction chemistry in cytochromes P450
We elucidate the hydroxylation of camphor by cytochrome P450 with the use of density functional and mixed quantum mechanics/molecular mechanics methods. Our results reveal that the enzyme catalyzes the hydrogen-atom abstraction step with a remarkably low free-energy barrier. This result provides a s...
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| Päätekijät: | , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2003
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC165819/ https://ncbi.nlm.nih.gov/pubmed/12771375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0732000100 |
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