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Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors

The transduction of type I interferon signals to the nucleus relies on activation of a protein complex, ISGF3, involving two signal transducers and activators of transcription (STAT) proteins, STAT1 and STAT2, and the interferon (IFN) regulatory factor (IRF) protein, p48/ISGF3γ. The STAT subunits ar...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Lau, Joe F., Parisien, Jean-Patrick, Horvath, Curt M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16536/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10860992/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.13.7278
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