Replication-Deficient Human Adenovirus Type 35 Vectors for Gene Transfer and Vaccination: Efficient Human Cell Infection and Bypass of Preexisting Adenovirus Immunity

Replication-deficient human adenovirus type 5 (Ad5) can be produced to high titers in complementing cell lines, such as PER.C6, and is widely used as a vaccine and gene therapy vector. However, preexisting immunity against Ad5 hampers consistency of gene transfer, immunological responses, and vector...

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Autors principals: Vogels, Ronald, Zuijdgeest, David, van Rijnsoever, Richard, Hartkoorn, Eric, Damen, Irma, de Béthune, Marie-Pierre, Kostense, Stefan, Penders, Germaine, Helmus, Niels, Koudstaal, Wouter, Cecchini, Marco, Wetterwald, Antoinette, Sprangers, Mieke, Lemckert, Angelique, Ophorst, Olga, Koel, Björn, van Meerendonk, Michelle, Quax, Paul, Panitti, Laura, Grimbergen, Jos, Bout, Abraham, Goudsmit, Jaap, Havenga, Menzo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC165227/
https://ncbi.nlm.nih.gov/pubmed/12857895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.15.8263-8271.2003
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