p38 Mitogen-Activated Protein Kinase Mediates Cell Death and p21-Activated Kinase Mediates Cell Survival during Chemotherapeutic Drug-induced Mitotic Arrest

Activation of the mitotic checkpoint by chemotherapeutic drugs such as taxol causes mammalian cells to arrest in mitosis and then undergo apoptosis. However, the biochemical basis of chemotherapeutic drug-induced cell death is unclear. Herein, we provide new evidence that both cell survival and cell...

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Bibliographic Details
Main Authors: Deacon, Karl, Mistry, Pratibha, Chernoff, Jonathan, Blank, Jonathan L., Patel, Rajnikant
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2003
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC165098/
https://ncbi.nlm.nih.gov/pubmed/12802076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-10-0653
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