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Aggrecanases and cartilage matrix degradation

The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called 'aggrecanases' that cleave the Glu(373)–Ala(374 )bond of the aggrecan core protein play a key role in the early stages of cartilage destruction in rheumatoid...

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Bibliografiske detaljer
Udgivet i:Arthritis Res Ther
Principais autores: Nagase, Hideaki, Kashiwagi, Masahide
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2003
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165039/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12718749/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/ar630
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