Protein Kinase B/Akt Binds and Phosphorylates PED/PEA-15, Stabilizing Its Antiapoptotic Action

The antiapoptotic protein PED/PEA-15 features an Akt phosphorylation motif upstream from Ser(116). In vitro, recombinant PED/PEA-15 was phosphorylated by Akt with a stoichiometry close to 1. Based on Western blotting with specific phospho-Ser(116) PED/PEA-15 antibodies, Akt phosphorylation of PED/PE...

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Bibliografske podrobnosti
Main Authors: Trencia, Alessandra, Perfetti, Anna, Cassese, Angela, Vigliotta, Giovanni, Miele, Claudia, Oriente, Francesco, Santopietro, Stefania, Giacco, Ferdinando, Condorelli, Gerolama, Formisano, Pietro, Beguinot, Francesco
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC164852/
https://ncbi.nlm.nih.gov/pubmed/12808093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.13.4511-4521.2003
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