Effects of Mutant Ubiquitin on ts1 Retrovirus-Mediated Neuropathology

ts1 is a temperature-sensitive mutant of Moloney murine leukemia virus that induces a rapid spongiform encephalopathy in mice infected as newborns. The pathological features include the formation of ubiquitinated inclusions resembling Lewy bodies. To determine how perturbation of the ubiquitin-prote...

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Bibliographic Details
Main Authors: Zhang, Mei, Thurig, Sherry, Tsirigotis, Maria, Wong, Paul K. Y., Reuhl, Kenneth R., Gray, Douglas A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC164816/
https://ncbi.nlm.nih.gov/pubmed/12805418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7193-7201.2003
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