Intranasal Immunization of Guinea Pigs with an Immunodominant Foot-and-Mouth Disease Virus Peptide Conjugate Induces Mucosal and Humoral Antibodies and Protection against Challenge

Guinea pigs immunized intranasally with a keyhole limpet hemocyanin-linked peptide, corresponding to the prominent G-H loop of the VP1 protein of foot-and-mouth disease virus, raised substantial levels of antipeptide and virus-neutralizing antibodies in sera and of peptide-specific secretory immunog...

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Main Authors: Fischer, D., Rood, D., Barrette, R. W., Zuwallack, A., Kramer, E., Brown, F., Silbart, L. K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC164810/
https://ncbi.nlm.nih.gov/pubmed/12805448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7486-7491.2003
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