A Constitutive Decay Element Promotes Tumor Necrosis Factor Alpha mRNA Degradation via an AU-Rich Element-Independent Pathway

Tumor necrosis factor alpha (TNF-α) expression is regulated by transcriptional as well as posttranscriptional mechanisms, the latter including the control of mRNA decay through an AU-rich element (ARE) in the 3′ untranslated region (UTR). Using two mutant cell lines deficient for ARE-mediated mRNA d...

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Autores principales: Stoecklin, Georg, Lu, Min, Rattenbacher, Bernd, Moroni, Christoph
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC164766/
https://ncbi.nlm.nih.gov/pubmed/12724409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.10.3506-3515.2003
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