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At Least 50% of Human-Specific HERV-K (HML-2) Long Terminal Repeats Serve In Vivo as Active Promoters for Host Nonrepetitive DNA Transcription

We report the first genome-wide comparison of in vivo promoter activities of a group of human-specific endogenous retroviruses in healthy and cancerous germ line tissues. To this end, we employed a recently developed technique termed genomic repeat expression monitoring. We found that at least 50% o...

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Main Authors: Buzdin, Anton, Kovalskaya-Alexandrova, Elena, Gogvadze, Elena, Sverdlov, Eugene
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1641792/
https://ncbi.nlm.nih.gov/pubmed/17041225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00871-06
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