Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress In Vitro and In Vivo

The human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) causes cell cycle arrest in G(2). Vpr-expressing cells display the hallmarks of certain forms of DNA damage, specifically activation of the ataxia telangiectasia mutated and Rad3-related kinase, ATR. However, evidence that Vpr fun...

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Detalhes bibliográficos
Main Authors: Zimmerman, Erik S., Sherman, Michael P., Blackett, Jana L., Neidleman, Jason A., Kreis, Christophe, Mundt, Pamela, Williams, Samuel A., Warmerdam, Maria, Kahn, James, Hecht, Frederick M., Grant, Robert M., de Noronha, Carlos M. C., Weyrich, Andrew S., Greene, Warner C., Planelles, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1641771/
https://ncbi.nlm.nih.gov/pubmed/16956949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01212-06
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