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Fiber and Penton Base Capsid Modifications Yield Diminished Adenovirus Type 5 Transduction and Proinflammatory Gene Expression with Retention of Antigen-Specific Humoral Immunity

Fiber and penton base capsid proteins of adenovirus type 5 (Ad5) mediate a well-characterized two-step entry pathway in permissive tissue culture cell lines. Fiber binds with high affinity to the cell surface coxsackievirus-and-adenovirus receptor (CAR), and penton base facilitates viral internaliza...

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Bibliografiske detaljer
Main Authors: Schoggins, John W., Falck-Pedersen, Erik
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1641751/
https://ncbi.nlm.nih.gov/pubmed/16943295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01359-06
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