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Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors.

Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a gene from the diploid organism Candida albicans that encodes a target of these inhibitors. A 2.1-kb port...

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Published in:Antimicrob Agents Chemother
Main Authors: Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, Li, W, Abruzzo, G K, Flattery, A, Bartizal, K, Mitchell, A, Kurtz, M B
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1997
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164147/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371352/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.11.2471
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