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A study to determine the pharmacokinetics and inflammatory fluid penetration of two doses of a solid formulation of the hexetil prodrug of a trinem, sanfetrinem (GV 104326).

The trinem sanfetrinem (GV 104326) was administered as the oral hexetil prodrug GV 118819X in two dose levels to six healthy volunteers. A single dose equivalent to 125 mg of sanfetrinem was administered, followed 6 weeks later by a single dose equivalent to 500 mg of sanfetrinem. The concentrations...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Wise, R, Andrews, J M, Da Ros, L, Child, J, Mortiboy, D
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164000/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9257756/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.8.1761
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