Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs.

The hypoxanthine phosphoribosyltransferase (HPRT) from Trypanosoma cruzi is a potential target for enzyme structure-based inhibitor design, based on previous studies which indicate that these parasites lack the metabolic enzymes required for de novo synthesis of purine nucleotides. By using a bacter...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Eakin, A E, Guerra, A, Focia, P J, Torres-Martinez, J, Craig, S P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9257742/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.8.1686
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!